The mouse is playing a pivotal role in understanding mammalian gene function. With its similar genome sequence, development, and physiology, the mouse is one of the preeminent model systems for the study of human development, normal biology, and disease. As part of the international effort to determine the function of every gene in the mammalian genome, The Toronto Centre for Phenogenomics, The Research Institute at The Hospital for Sick Children, and Mount Sinai Hospital's, Samuel Lunenfeld Research Institute are collaborating in Canada's contribution to the coordinated international effort to:

  • Produce and phenotype single-gene knockout mice for 5,000 different genes in the next 5 years
  • Generate Cre driver mouse lines for the developing mouse embryo and the adult mouse
We are leading or participating in three projects to meet these goals:
  • NorCOMM2 – produce and phenotype 150 knockout mouse lines nominated by Canadian scientists
  • NorCOMM2LS – generate 75 new Cre driver lines
  • KOMP2-DTCC – produce 150 knockout mouse lines and phenotype up to 200 embryonic lethal mouse lines

image of mouse in front of Helix